Interactive analysis of outcomes in singleton gestations with short cervix (≤25 mm) and no prior preterm birth
Source: Conde-Agudelo A, Romero R, da Fonseca E, Hassan SS, Nicolaides KH. Vaginal progesterone decreases the risk of preterm birth and adverse perinatal outcomes in singleton gestations with a midtrimester sonographic short cervix (≤25 mm) and without a history of spontaneous preterm birth. Am J Obstet Gynecol. 2025 Dec;233:e234–e237. IPD subgroup meta-analysis of 3 RCTs (n=686).
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Statistical Significance
Statistically significant (P<.05)
Trend toward benefit (P .05–.20)
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Study details: IPD subgroup analysis of 3 double-blind, placebo-controlled RCTs (Fonseca 2007, Hassan 2011, Norman 2016). Population: 686 women with singleton gestations, midtrimester CL ≤25 mm, no prior spontaneous PTB. Vaginal progesterone (n=351) vs. placebo (n=335). Fixed-effect model used when I²<30%; random-effects when I²≥30%.
For educational purposes only. Clinical decisions should consider individual patient factors. Full text available at doi.org/10.1016/j.ajog.2025.07.003