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PreNOC: Preterm Neonatal Outcome Calculator

PreNOC: Preterm Neonatal Outcome Calculator

Evidence-based periviability and preterm outcome data
📄 12 References 10 Major Datasets 20-34 Weeks Survival + Morbidity Risk Modifiers
Clinical Reference Tool. This tool synthesizes published survival and outcome data from multiple large cohort studies and registries for clinical reference. Data represent population averages and cannot predict outcomes for individual patients. Outcomes depend heavily on institutional resources, philosophy of care, and individual clinical circumstances. Hospital variation at 22-23 weeks accounts for more outcome variation than any patient factor.
Patient Information
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References
  1. Bell EF et al. Mortality, in-hospital morbidity, care practices, and 2-year outcomes for extremely preterm infants in the US, 2013-2018. JAMA. 2022;327(3):248-263. DOI: 10.1001/jama.2021.23580. PMID: 35040888.
  2. Rysavy MA et al. Between-hospital variation in treatment and outcomes in extremely preterm infants. N Engl J Med. 2015;372(19):1801-1811. DOI: 10.1056/NEJMoa1410689. PMID: 25946279.
  3. Younge N et al. Survival and neurodevelopmental outcomes among periviable infants. N Engl J Med. 2017;376(7):617-628. DOI: 10.1056/NEJMoa1605566. PMID: 28199816.
  4. Stoll BJ et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012. JAMA. 2015;314(10):1039-1051. DOI: 10.1001/jama.2015.10244. PMID: 26348753.
  5. Costeloe KL et al. Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICure studies). BMJ. 2012;345:e7976. DOI: 10.1136/bmj.e7976. PMID: 23212881.
  6. Moore T et al. Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies. BMJ. 2012;345:e7961. DOI: 10.1136/bmj.e7961. PMID: 23212880.
  7. Serenius F et al. Neurodevelopmental outcome in extremely preterm infants at 2.5 years after active perinatal care in Sweden (EXPRESS). JAMA. 2013;309(17):1810-1820. DOI: 10.1001/jama.2013.3786. PMID: 23632725.
  8. Qattea I et al. Survival of infants born at periviable gestation: the US national database. Lancet Reg Health Am. 2022;14:100330. DOI: 10.1016/j.lana.2022.100330. PMID: 36777383.
  9. Rysavy MA et al. Assessment of an updated Neonatal Research Network extremely preterm birth outcome model in the Vermont Oxford Network. JAMA Pediatr. 2020;174(5):e196294. DOI: 10.1001/jamapediatrics.2019.6294. PMID: 32119065.
  10. Carlo WA et al. Association of antenatal corticosteroids with mortality and neurodevelopmental outcomes among infants born at 22 to 25 weeks' gestation. JAMA. 2011;306(21):2348-2358. DOI: 10.1001/jama.2011.1752. PMID: 22147379.
  11. Higgins BV, Baer RJ, Steurer MA, Karvonen KL, Oltman SP, Jelliffe-Pawlowski LL, Rogers EE. Resuscitation, survival and morbidity of extremely preterm infants in California 2011-2019. J Perinatol. 2024 Feb;44(2):209-216. DOI: 10.1038/s41372-023-01774-6. PMID: 37689808; PMCID: PMC10844092.
  12. Claas MJ, Bruinse HW, Koopman C, van Haastert IC, Peelen LM, de Vries LS. Two-year neurodevelopmental outcome of preterm born children ≤ 750 g at birth. Arch Dis Child Fetal Neonatal Ed. 2011 May;96(3):F169-77. DOI: 10.1136/adc.2009.174433. PMID: 20530098.
ObGyn Intelligence - Evidence Matters
ObMD.com | PreNOC: Preterm Neonatal Outcome Calculator
Developed by Amos Grünebaum, MD

Data synthesized from NICHD NRN, EPICure, EXPRESS, California population study, US National Database, and VON.
This tool is for clinical reference only. It does not predict individual outcomes.