Clinical Definitions & Guidelines
1
Practice Committee of the American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril. 2020;113(3):533–535.
Source for clinical definition of infertility: 12 months for women <35, 6 months for women ≥35.
2
ACOG Committee on Gynecologic Practice and Practice Committee. Female Age-Related Fertility Decline. Committee Opinion No. 589. Obstet Gynecol. 2014;123(3):719–721. Reaffirmed 2022.
Source for age-related recommendations and earlier evaluation for women ≥35, ≥40.
3
Thoma ME, McLain AC, Louis JF, et al. Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach. Fertil Steril. 2013;99(5):1324–1331.e1.
US infertility prevalence data used to contextualize how common these concerns are.
4
Sharlip ID, Jarow JP, Belker AM, et al. Best practice policies for male infertility. Fertil Steril. 2002;77(5):873–882.
Male factor accounts for 40–50% of fertility challenges — basis for recommending semen analysis as a first-line test.
5
Practice Committee of the American Society for Reproductive Medicine. Diagnostic evaluation of the infertile female: a committee opinion. Fertil Steril. 2015;103(6):e44–e50.
Source for recommended initial diagnostic workup in the ObGyn office setting.
6
Mumford SL, Steiner AZ, Pollack AZ, et al. The utility of menstrual cycle length as an indicator of cumulative hormonal exposure. J Clin Endocrinol Metab. 2012;97(10):E1871–E1879.
Basis for using cycle regularity as a clinical proxy for ovulatory function.
7
Practice Committee of ASRM; Practice Committee of SART. Mature oocyte cryopreservation: a guideline. Fertil Steril. 2013;99(1):37–43.
Basis for fertility preservation counseling recommendations included in this tool.
8
ESHRE Guideline Group on POI; Webber L, Davies M, Anderson R, et al. ESHRE Guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2016;31(5):926–937.
Diagnostic criteria for POI: FSH >25 IU/L on two occasions ≥4 weeks apart, before age 40. Basis for POI evaluation pathway in this tool.
9
Harlow SD, Gass M, Hall JE, et al; STRAW+10 Collaborative Group. Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab. 2012;97(4):1159–1168.
STRAW+10 staging system for the menopausal transition — framework used for perimenopause classification in this tool.
10
Nelson LM. Clinical practice. Primary ovarian insufficiency. N Engl J Med. 2009;360(6):606–614.
Prevalence (~1% under 40, ~0.1% under 30), spontaneous conception rate (5–10%), and long-term health implications of POI including bone and cardiovascular risk.
11
Brannigan RE, Hermanson L, Kaczmarek J, Kim SK, Kirkby E, Tanrikut C. Updates to male infertility: AUA/ASRM guideline (2024). J Urol. 2024;212(6):789–799. doi:10.1097/JU.0000000000004180
Strong Recommendation (Grade B): one or more semen analyses required during initial male fertility evaluation. Revised thresholds for karyotype testing, indications for pelvic MRI, and guidance on testicular sperm in non-azoospermic males.
12
World Health Organization. WHO Laboratory Manual for the Examination and Processing of Human Semen. 6th ed. Geneva: WHO; 2021.
Current global standard for semen analysis interpretation. Lower reference limits used in this tool: volume ≥1.4 mL, concentration ≥16 million/mL, total sperm ≥39 million, progressive motility ≥30%, total motility ≥40%, normal morphology ≥4%, vitality ≥54%.
13
National Institute for Health and Care Excellence (NICE). Fertility problems: assessment and treatment. Clinical guideline CG156. London: NICE; 2013 (updated 2017).
Recommends semen analysis interpreted against WHO reference values. If first result is abnormal, repeat confirmatory test 3 months later to allow completion of spermatogenesis cycle. Earlier referral for women ≥36 years or known predisposing factors.
This tool was developed to address a documented access gap: patients with fertility concerns are frequently denied ObGyn appointments due to insurance coding issues, despite guidelines recommending that the initial fertility evaluation take place in a gynecologist's office. The tool walks patients through the clinical questions their ObGyn should ask, generates a personalized summary of appropriate initial tests, and identifies the minority of cases where direct specialist referral is appropriate. No patient data is collected, stored, or transmitted.