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Second Trimester · 100 Questions

Second Trimester Pregnancy
100 Questions

Click any button to open Claude or ChatGPT with the question pre-loaded — tailored for patients or clinicians, with instructions to cite peer-reviewed sources only.

Developed by Amos Grünebaum, MD · Maternal-Fetal Medicine
Important: AI may occasionally generate inaccurate citations. Always verify references independently before clinical use. This tool instructs the AI to cite only peer-reviewed journals or major guidelines (ACOG, SMFM, CDC, NIH, WHO).
1
Normal Second Trimester Development
10 questions
1
What happens developmentally in the second trimester week by week?
Patient Claude GPT
Clinician Claude GPT
2
When can fetal sex be determined by ultrasound?
Patient Claude GPT
Clinician Claude GPT
3
What is quickening and when does it occur?
Patient Claude GPT
Clinician Claude GPT
4
How much does the fetus weigh at 20 weeks?
Patient Claude GPT
Clinician Claude GPT
5
What is the limit of viability and what does the evidence show?
Patient Claude GPT
Clinician Claude GPT
6
How does the placenta function in the second trimester?
Patient Claude GPT
Clinician Claude GPT
7
What fetal movements are normal in the second trimester?
Patient Claude GPT
Clinician Claude GPT
8
How does the uterus grow during the second trimester?
Patient Claude GPT
Clinician Claude GPT
9
What is fundal height and how is it measured?
Patient Claude GPT
Clinician Claude GPT
10
What is the role of amniotic fluid in the second trimester?
Patient Claude GPT
Clinician Claude GPT
2
Anatomy Ultrasound and Fetal Surveillance
10 questions
11
What is the anatomy ultrasound and when is it performed?
Patient Claude GPT
Clinician Claude GPT
12
What structures are evaluated on the 20-week anatomy scan?
Patient Claude GPT
Clinician Claude GPT
13
What are soft markers on ultrasound and what do they mean?
Patient Claude GPT
Clinician Claude GPT
14
What is an echogenic intracardiac focus and should parents be concerned?
Patient Claude GPT
Clinician Claude GPT
15
What is a choroid plexus cyst and what does it indicate?
Patient Claude GPT
Clinician Claude GPT
16
What is fetal growth restriction and how is it detected in the second trimester?
Patient Claude GPT
Clinician Claude GPT
17
What is a biophysical profile and when is it used?
Patient Claude GPT
Clinician Claude GPT
18
What is Doppler velocimetry and when is it indicated?
Patient Claude GPT
Clinician Claude GPT
19
What findings on anatomy ultrasound require referral to MFM?
Patient Claude GPT
Clinician Claude GPT
20
What is the difference between a level 1 and level 2 ultrasound?
Patient Claude GPT
Clinician Claude GPT
3
Second Trimester Screening and Diagnosis
10 questions
21
What is the quad screen and what does it measure?
Patient Claude GPT
Clinician Claude GPT
22
What is the role of AFP in second trimester screening?
Patient Claude GPT
Clinician Claude GPT
23
What is an elevated MSAFP and what are the causes?
Patient Claude GPT
Clinician Claude GPT
24
What is amniocentesis and what are its risks?
Patient Claude GPT
Clinician Claude GPT
25
When is amniocentesis recommended over cell-free DNA screening?
Patient Claude GPT
Clinician Claude GPT
26
What is the difference between amniocentesis and CVS?
Patient Claude GPT
Clinician Claude GPT
27
What is a fetal echocardiogram and who should have one?
Patient Claude GPT
Clinician Claude GPT
28
What is integrated screening and how does it compare to sequential screening?
Patient Claude GPT
Clinician Claude GPT
29
What genetic conditions are detected by amniocentesis but not cell-free DNA?
Patient Claude GPT
Clinician Claude GPT
30
What is a fetal MRI and when is it used in the second trimester?
Patient Claude GPT
Clinician Claude GPT
4
Cervical Insufficiency and Preterm Birth Prevention
10 questions
31
What is cervical insufficiency and how is it diagnosed?
Patient Claude GPT
Clinician Claude GPT
32
What is a short cervix and at what length is intervention recommended?
Patient Claude GPT
Clinician Claude GPT
33
What is the evidence for vaginal progesterone for short cervix?
Patient Claude GPT
Clinician Claude GPT
34
What is a cervical cerclage and who is a candidate?
Patient Claude GPT
Clinician Claude GPT
35
What is the difference between history-indicated and ultrasound-indicated cerclage?
Patient Claude GPT
Clinician Claude GPT
36
What is the PREVENT trial and what did it show about cerclage?
Patient Claude GPT
Clinician Claude GPT
37
What is the arabin pessary and what is the evidence for its use?
Patient Claude GPT
Clinician Claude GPT
38
What are the risk factors for spontaneous preterm birth?
Patient Claude GPT
Clinician Claude GPT
39
What is cervical length screening and when should it be performed?
Patient Claude GPT
Clinician Claude GPT
40
What lifestyle modifications reduce the risk of preterm birth?
Patient Claude GPT
Clinician Claude GPT
5
Common Second Trimester Symptoms and Concerns
10 questions
41
What causes round ligament pain in the second trimester?
Patient Claude GPT
Clinician Claude GPT
42
What causes back pain in pregnancy and how is it managed?
Patient Claude GPT
Clinician Claude GPT
43
What is diastasis recti and when does it develop?
Patient Claude GPT
Clinician Claude GPT
44
What causes leg cramps in pregnancy and what is the evidence for treatment?
Patient Claude GPT
Clinician Claude GPT
45
What is pelvic girdle pain and how is it managed?
Patient Claude GPT
Clinician Claude GPT
46
What causes skin changes like linea nigra and melasma in pregnancy?
Patient Claude GPT
Clinician Claude GPT
47
What is the evidence on sleeping position in the second trimester?
Patient Claude GPT
Clinician Claude GPT
48
What causes shortness of breath in the second trimester?
Patient Claude GPT
Clinician Claude GPT
49
What dental changes occur in pregnancy and what care is safe?
Patient Claude GPT
Clinician Claude GPT
50
What causes nosebleeds and gum bleeding in the second trimester?
Patient Claude GPT
Clinician Claude GPT
6
Nutrition, Weight Gain, and Exercise
10 questions
51
What is the recommended weight gain in the second trimester?
Patient Claude GPT
Clinician Claude GPT
52
What are the caloric needs in the second trimester?
Patient Claude GPT
Clinician Claude GPT
53
What exercise is safe and beneficial in the second trimester?
Patient Claude GPT
Clinician Claude GPT
54
What are the contraindications to exercise during the second trimester?
Patient Claude GPT
Clinician Claude GPT
55
What is the evidence on iron supplementation in the second trimester?
Patient Claude GPT
Clinician Claude GPT
56
What is gestational anemia and when should it be treated?
Patient Claude GPT
Clinician Claude GPT
57
What foods remain off-limits in the second trimester?
Patient Claude GPT
Clinician Claude GPT
58
What is the evidence on omega-3 supplementation in pregnancy?
Patient Claude GPT
Clinician Claude GPT
59
How does gestational weight gain affect perinatal outcomes?
Patient Claude GPT
Clinician Claude GPT
60
What is the evidence on probiotic supplementation during pregnancy?
Patient Claude GPT
Clinician Claude GPT
7
Gestational Diabetes
10 questions
61
What is gestational diabetes and how is it diagnosed?
Patient Claude GPT
Clinician Claude GPT
62
What is the one-step versus two-step approach to GDM screening?
Patient Claude GPT
Clinician Claude GPT
63
When should GDM screening be performed?
Patient Claude GPT
Clinician Claude GPT
64
What are the risks of gestational diabetes for the mother and baby?
Patient Claude GPT
Clinician Claude GPT
65
What is the first-line treatment for gestational diabetes?
Patient Claude GPT
Clinician Claude GPT
66
What glucose targets are recommended for gestational diabetes?
Patient Claude GPT
Clinician Claude GPT
67
When is insulin required for gestational diabetes?
Patient Claude GPT
Clinician Claude GPT
68
How does metformin compare to insulin for gestational diabetes?
Patient Claude GPT
Clinician Claude GPT
69
How does GDM affect delivery planning and timing?
Patient Claude GPT
Clinician Claude GPT
70
What is the long-term risk of type 2 diabetes after gestational diabetes?
Patient Claude GPT
Clinician Claude GPT
8
Hypertensive Disorders in the Second Trimester
10 questions
71
What is chronic hypertension in pregnancy and how is it managed?
Patient Claude GPT
Clinician Claude GPT
72
What is the difference between chronic hypertension and preeclampsia?
Patient Claude GPT
Clinician Claude GPT
73
What is the evidence for low-dose aspirin in preeclampsia prevention?
Patient Claude GPT
Clinician Claude GPT
74
What is the ACOG definition of preeclampsia?
Patient Claude GPT
Clinician Claude GPT
75
What blood pressure threshold requires treatment in pregnancy?
Patient Claude GPT
Clinician Claude GPT
76
What antihypertensive medications are safe in the second trimester?
Patient Claude GPT
Clinician Claude GPT
77
What is the role of uterine artery Doppler in preeclampsia prediction?
Patient Claude GPT
Clinician Claude GPT
78
What are the warning signs of severe preeclampsia?
Patient Claude GPT
Clinician Claude GPT
79
What is HELLP syndrome and how is it recognized?
Patient Claude GPT
Clinician Claude GPT
80
What is superimposed preeclampsia and how is it diagnosed?
Patient Claude GPT
Clinician Claude GPT
9
Fetal Anomalies and Diagnosis
10 questions
81
What are the most common fetal structural anomalies detected at anatomy scan?
Patient Claude GPT
Clinician Claude GPT
82
What is ventriculomegaly and what does it mean for the baby?
Patient Claude GPT
Clinician Claude GPT
83
What is spina bifida and what are the management options after prenatal diagnosis?
Patient Claude GPT
Clinician Claude GPT
84
What is a congenital heart defect and how is it managed prenatally?
Patient Claude GPT
Clinician Claude GPT
85
What is a cleft lip and palate and how is it diagnosed prenatally?
Patient Claude GPT
Clinician Claude GPT
86
What are the options when a lethal fetal anomaly is diagnosed?
Patient Claude GPT
Clinician Claude GPT
87
What is gastroschisis versus omphalocele and how are they managed?
Patient Claude GPT
Clinician Claude GPT
88
What is renal agenesis and what are its implications?
Patient Claude GPT
Clinician Claude GPT
89
What is hydrops fetalis and what causes it?
Patient Claude GPT
Clinician Claude GPT
90
What is the role of fetal intervention for anomalies diagnosed in the second trimester?
Patient Claude GPT
Clinician Claude GPT
10
Infections and Exposures in the Second Trimester
10 questions
91
What is the risk of CMV infection in the second trimester?
Patient Claude GPT
Clinician Claude GPT
92
What is toxoplasmosis and how is it prevented in pregnancy?
Patient Claude GPT
Clinician Claude GPT
93
What is the impact of Zika virus exposure in the second trimester?
Patient Claude GPT
Clinician Claude GPT
94
What is parvovirus B19 and what is the risk to the fetus?
Patient Claude GPT
Clinician Claude GPT
95
What is the risk of Group B Streptococcus in the second trimester?
Patient Claude GPT
Clinician Claude GPT
96
How is UTI managed in the second trimester?
Patient Claude GPT
Clinician Claude GPT
97
What is bacterial vaginosis and does treatment improve pregnancy outcomes?
Patient Claude GPT
Clinician Claude GPT
98
What is the evidence on influenza vaccination in the second trimester?
Patient Claude GPT
Clinician Claude GPT
99
What is the risk of COVID-19 infection in the second trimester?
Patient Claude GPT
Clinician Claude GPT
100
What sexually transmitted infections require treatment during the second trimester?
Patient Claude GPT
Clinician Claude GPT