ObGyn Intelligence
ObGyn Intelligence
← All Tools

Pregnancy Tests & Labs
100 Questions

Blood tests, urine tests, cultures, genetic screens, and more — the 100 most important lab questions in pregnancy. Click any button to open Claude or ChatGPT with the question pre-loaded, tailored for patients or clinicians.

Developed by Amos Grünebaum, MD · Maternal-Fetal Medicine
Important: AI may occasionally generate inaccurate citations. Always verify references independently before clinical use. This tool instructs the AI to cite only peer-reviewed journals or major guidelines (ACOG, SMFM, CDC, NIH, WHO).
1
Routine First Prenatal Blood Tests
10 questions
1
What does a complete blood count measure in early pregnancy and what is normal?
2
What is blood type and Rh factor testing and why is it critical in pregnancy?
3
What is an antibody screen in pregnancy and what does a positive result mean?
4
What is rubella immunity testing and what happens if a patient is not immune?
5
What is varicella immunity testing and what is done if immunity is absent?
6
What is hepatitis B surface antigen testing and what does a positive result mean?
7
What is HIV testing in pregnancy and when should it be repeated?
8
What is syphilis testing in pregnancy and what test is used?
9
What is gonorrhea and chlamydia testing in pregnancy and when is it repeated?
10
What is a urine culture at the first prenatal visit and why is it done even without symptoms?
2
Thyroid and Endocrine Tests
10 questions
11
What is TSH testing in pregnancy and what is a normal range in the first trimester?
12
What is the difference between subclinical and overt hypothyroidism in pregnancy?
13
When should free T4 be checked in addition to TSH in pregnancy?
14
What is Graves disease in pregnancy and how is it monitored with lab tests?
15
What is thyroid peroxidase antibody testing and when is it relevant in pregnancy?
16
What is a 1-hour glucose challenge test and what is the threshold for abnormal?
17
What is a 3-hour glucose tolerance test and what are the diagnostic criteria for GDM?
18
What is the difference between the Carpenter-Coustan and NDDG criteria for GDM?
19
What is HbA1c in pregnancy and when is it used?
20
What is a fasting glucose test and when is it used instead of the glucose challenge?
3
Anemia and Iron Studies
10 questions
21
What hemoglobin level defines anemia in pregnancy by trimester?
22
What is a serum ferritin and why is it the best test for iron deficiency in pregnancy?
23
What is a serum iron and TIBC and when are they used in pregnancy?
24
What is the difference between iron deficiency anemia and anemia of pregnancy?
25
What is a peripheral blood smear and when is it ordered in pregnancy?
26
What is a reticulocyte count and what does it tell us about anemia in pregnancy?
27
What is hemoglobin electrophoresis and who should be screened in pregnancy?
28
What is sickle cell trait versus sickle cell disease and how does it affect pregnancy?
29
What is thalassemia screening in pregnancy and who needs it?
30
What is G6PD deficiency and why is it relevant in pregnancy?
4
Infectious Disease Screening
10 questions
31
What is the hepatitis C antibody test and who should be screened in pregnancy?
32
What is cytomegalovirus serology in pregnancy and when is it ordered?
33
What is toxoplasma IgG and IgM and when is testing indicated?
34
What is parvovirus B19 serology and when should it be checked?
35
What is Zika virus testing and when is it recommended?
36
What is a wet prep and when is it used in pregnancy?
37
What is a vaginal culture for Group B Streptococcus and when is it performed?
38
What is bacterial vaginosis diagnosis in pregnancy and what tests confirm it?
39
What is a trichomoniasis test in pregnancy and how is it diagnosed?
40
What is herpes simplex virus serology and when is it ordered in pregnancy?
5
Urine Tests in Pregnancy
10 questions
41
What is a urinalysis in pregnancy and what findings are abnormal?
42
What is a urine culture and sensitivity and when is it indicated?
43
What is asymptomatic bacteriuria and why must it be treated in pregnancy?
44
What is proteinuria in pregnancy and how is it quantified?
45
What is a urine protein-to-creatinine ratio and when is it used?
46
What is a 24-hour urine protein collection and when is it still indicated?
47
What is glucosuria in pregnancy and when is it concerning?
48
What is a urine drug screen in pregnancy and what is the standard of care?
49
What is hematuria in pregnancy and how is it evaluated?
50
What is leukocyte esterase and nitrites on urine dipstick and what do they indicate?
6
Preeclampsia and Hypertension Labs
10 questions
51
What labs are ordered when preeclampsia is suspected?
52
What is a platelet count in preeclampsia and at what level is it concerning?
53
What are liver enzymes in preeclampsia and what elevation is significant?
54
What is serum creatinine in preeclampsia and what level indicates severe disease?
55
What is LDH in HELLP syndrome and what level is diagnostic?
56
What is a peripheral smear finding in HELLP syndrome?
57
What is serum uric acid in preeclampsia and is it useful clinically?
58
What is the PlGF test and what is its role in preeclampsia prediction?
59
What is the sFlt-1 to PlGF ratio and what does it predict?
60
What labs indicate imminent delivery in severe HELLP syndrome?
7
Genetic and Carrier Screening Tests
10 questions
61
What is cystic fibrosis carrier screening and who should be offered it?
62
What is spinal muscular atrophy carrier screening and what does a positive result mean?
63
What is fragile X premutation carrier testing and when is it indicated?
64
What is expanded carrier screening and what conditions does it cover?
65
What is cell-free fetal DNA in maternal blood and what does it screen for?
66
What is a positive cell-free DNA result and what are the next steps?
67
What is a failed or no-result cell-free DNA test and what should be done?
68
What is PAPP-A and what does a low level predict beyond Down syndrome?
69
What is inhibin A in the quad screen and what does an elevated level indicate?
70
What is unconjugated estriol in the quad screen and what does a low level mean?
8
Coagulation and Autoimmune Tests
10 questions
71
What is antiphospholipid antibody testing and when is it ordered in pregnancy?
72
What is lupus anticoagulant and how is it tested?
73
What is anticardiolipin antibody and what titer level is clinically significant?
74
What is anti-beta-2 glycoprotein I antibody and when is it tested?
75
What is a thrombophilia panel in pregnancy and who should be screened?
76
What is Factor V Leiden and how does it affect pregnancy?
77
What is prothrombin gene mutation and what is its risk in pregnancy?
78
What is MTHFR mutation testing and is it clinically useful in pregnancy?
79
What is protein C and protein S testing and when is it indicated?
80
What is antithrombin III deficiency and how does it affect pregnancy management?
9
Third Trimester and Antepartum Tests
10 questions
81
What is repeat hemoglobin or hematocrit testing in the third trimester?
82
What is repeat syphilis testing in the third trimester and who needs it?
83
What is repeat HIV testing in the third trimester and who should be retested?
84
What is repeat gonorrhea and chlamydia testing and when is it recommended?
85
What is Group B Strep culture at 35 to 37 weeks and what does a positive result mean?
86
What is repeat hepatitis B testing in the third trimester and who needs it?
87
What is a nonstress test and what lab values support or replace it?
88
What is a biophysical profile and how do labs complement it?
89
What is cord blood gas analysis at delivery and what values indicate acidosis?
90
What is a Kleihauer-Betke test and when is it ordered postpartum?
10
Postpartum and Newborn Labs
10 questions
91
What is a postpartum hemoglobin check and when is it indicated?
92
What is Rh immunoglobulin indication and what test determines the dose needed?
93
What is a rubella titer postpartum and what is done if immunity is absent?
94
What is a postpartum thyroid function test and who should have one?
95
What is a postpartum glucose tolerance test after gestational diabetes?
96
What is newborn blood spot screening and what conditions does it test for?
97
What is a newborn bilirubin level and when is treatment indicated?
98
What is a newborn complete blood count and when is it ordered?
99
What is a newborn blood culture and when is it indicated?
100
What is a cord blood banking and what is the evidence for its clinical utility?